MADX

Babirus Partners MADX Join the revolution in molecular diagnostics of food allergies and food intolerances with Madx!
For laboratories, doctors and clinics, as scientists we offer future-oriented, intuitive immunodiagnostic all-in-one solutions on a molecular basis, thus establishing a new gold standard in the interest of all stakeholders. Molecular diagnostics allow for a flexible, reliable, and affordable profiling of a patient’s sensitization status.

Advanced Allergy Testing with ALEX

ALEX is the first in vitro multiplex allergy test allowing simultaneous measurement of total IgE (tIgE) and specific IgE (sIgE) against a plethora of allergen extracts and molecular allergens.

Based on our test panels composition of allergen extracts and molecular allergens, a near complete picture of each patient’s sensitization status is obtained. ALEX is based on our proprietary nano-bead technology. Every allergen (extract) can be individually optimized for production. The flexible analysis software, allows our customers to analyze tailormade allergen panels as they see fit for their clinical needs – Multiplex on demand.

The ALEX assay protocol integrates a powerful Cross-reactive Carbohydrate Deteminants (CCDs) inhibitor during serum incubation, which will clear up your specific IgE results. This reduces the interpretative burden for physicians of CCD positive patients and increases the specificity of our test results.

Simultaneous measurement of total and specific IgE
Near-complete allergen panel, individually optimized
Multiplex test with on-demand panel composition
Integrated CCD inhibition

Understanding Allergies and Anaphylaxis

Between 1.6% to 5.1% of Adults

have suffered a life-threatening allergic reaction. Food and insect venom are the most common cause of anaphylactic reactions.

Wood RA;Camargo CA;Lieberman P;Sampson HA;Schwartz LB;Zitt M;Collins C;Tringale M;Wilkinson M;Boyle J;Simons FE; (n.d.). Anaphylaxis in America: The prevalence and characteristics of anaphylaxis in the United States. The Journal of Allergy and Clinical Immunology. Retrieved November 12, 2021

IgE Food Explorer is an allergy blood test (also referred to as a specific IgE test). It measures the concentration of specific IgE antibodies in the blood to different antigens, including foods, pollens, mites, insect venom, and more. The detection of IgE indicates SENSITIZATION to a
specific allergen. It is important to understand that being IgE sensitized and having positive IgE antibodies does not guarantee a clinical response. In fact, patients with positive IgE test results for a specific antigen fall into two categories:

1.IgE sensitized and allergic

2.IgE sensitized and non-allergic

Extract-level IgE testing alone may not distinguish between these two patient groups. Component IgE testing with IgE Allergy Explorer can provide additional insight and help practitioners narrow in on a clinical diagnosis in context with patient history and symptoms.

Exploring Extract and Component Testing

1.Whole allergen (extract) tests that can help rule in or out the specific type of allergy sensitization.

2.Allergen component tests that drill down into the exact allergenic protein driving symptoms.

IgE Food Explorer's Component Allergy Testing Allows For:

1. Determination of cross-reactive allergens.

Cross-reactivity occurs when two different antigens have a similar makeup at the molecular level, and a person’s immune system reacts to both allergens. For example, someone may be IgE sensitized to birch pollen but may also react to certain fruits.

2. Assessing the severity of the immune response or reaction.

Specific components (or proteins) are associated with a higher risk of severe or systemic reactions than others. For example, only certain peanut proteins (components) are associated with anaphylaxis.

3. Facilitating better lifestyle management.

For example, if a patient is negative result for certain components in cow’s milk, they may be able to consume dairy that has been baked but will need to avoid raw.